From 2000 to 2013, soybean [Glycine max (L.) Merr] grain commodity price increased by almost 300% generating interest in inputs to maximize yield. The objective of this study was to evaluate the effect of commonly sold inputs on soybean grain yield in enhanced (high-input) and traditional (low-input) production systems. Inputs evaluated included: Rhizobia inoculant, gypsum, Mn fertilizer, insecticide, and fungicide. A 16 site-year trial was established in Ohio during 2013 and 2014. Rhizobia inoculant was seed-applied before planting, gypsum was applied at the VC growth stage (unrolled unifoliate leaves), and foliar Mn, insecticide, and fungicide were applied at the R3 growth stage (initial pod development). There was very little yield response associated with the inoculant, gypsum, Mn, and insecticide due to fields being in a corn-soybean rotation, no S deficiencies, limited Mn deficiencies, and limited insect defoliation. The omission of fungicide from the enhanced production system reduced yield in 5 of 16 site-years by 0.21 to 0.79 Mg ha-1, but its addition to a traditional system increased yield significantly at 1 of 16 site-years by 0.47 Mg ha-1. Across the 16 site-years, soybean yield was influenced by fungicide application when fields had disease present, above average yield (3.5 Mg ha-1), and received 25 cm of precipitation in June and July. The data indicate a very small potential for high-input production systems to enhance crop yield without the presence of diseases, insects, or nutrient deficiencies.